Clinical abuse potential study - MORPHABOND ER Vs MORPHABOND ER

Clinical abuse potential study

Whether Taken Intact or Intranasally, There Was No Significant Preference for the Intranasal Route1,2

Mean Drug Liking

Mean Take Drug Again

 
MORPHABOND ER retains its extended-release properties even if manipulated
Abuse of MORPHABOND ER is still possible by intranasal, intravenous, and oral routes
Abuse of MORPHABOND ER is still possible by intranasal, intravenous, and oral routes

Study design:

The intranasal abuse potential and relative bioavailability of MORPHABOND ER

was evaluated in a randomized, double-blind, double-dummy, placebo-controlled, single-dose, 4-way crossover study in 25 nondependent recreational opioid users comparing crushed intranasal MORPHABOND ER 60 mg, crushed intranasal MS Contin® 60 mg, and intact oral MORPHABOND ER 60 mg.

  • Primary endpoint: mean maximum effect (Emax) for Drug Liking between crushed intranasal MORPHABOND ER and crushed intranasal MS Contin®
  • Secondary comparisons for the primary endpoint included Emax for intact oral MORPHABOND ER compared with crushed intranasal MS Contin® and crushed intranasal MORPHABOND ER
  • Other secondary endpoints included Take Drug Again assessments and determining the relative bioavailability of morphine in plasma for crushed intranasal and intact oral MORPHABOND ER compared with crushed intranasal MS Contin®
  • Drug Liking (primary) and Take Drug Again (secondary) endpoints were measured on a 100-mm bipolar VAS where 50 represents a neutral response, 0 represents the strongest negative response, and 100 represents the strongest positive response

Page navigation - MORPHABOND ER Crushed vs Intact

Why Abuse-Deterrent Formulations

Prescription opioid abuse continues to grow. Abuse-deterrent formulations are just one potential solution to this complex
societal problem

The MORPHABOND ER Savings Program

Eligible commercially insured patients may pay as little as $10 a month
Please see Eligibility Criteria and Terms and Conditions below.

MORPHABOND ER Dosing

MORPHABOND ER has a 1-to-1 conversion from MS Contin®