In vitro studies

In vitro studies

MORPHABOND ER Is Formulated to Reduce Abuse1,2

More than 2000 in vitro tests were conducted to ensure manipulation difficulty

PHYSICAL MANIPULATION

MORPHABOND ER demonstrated increased resistance to cutting, crushing, or breaking using a variety of tools relative to MS Contin®

CHEMICAL EXTRACTION

Both intact and manipulated MORPHABOND ER tablets resisted extraction in selected household and laboratory solvents under various conditions, including selected pretreatments

SYRINGEABILITY

The formulation of MORPHABOND ER formed a viscous mass that resists passage through a needle when placed in a liquid environment

 
MORPHABOND ER demonstrated physicochemical properties expected to reduce abuse by injection and intranasal administration. However, abuse by these routes is still possible

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